Research

The main objective of our research is the development of state-of-the-art analytical techniques that allow for the advanced study of metal species' chemistry and biochemistry in environmental and biological systems. Currently, we are developing analytical methods in the following areas:

Determination of metal-containing nanoparticles in biological and environmental systems
To achieve this we are currently developing a range of single particle (sp) ICP-MS techniques. In addition, separation techniques suitable for nanoparticle separation, i.e. ion mobility spectrometry and hydrodynamic chromatography, online and offline with ICP-MS are being further developed. The objective is to optimize these approaches for the determination of metal-containing nanoparticles in environmental and biological samples.

Metal Speciation Analysis of As, Hg, Se, Sb, Sn and Cr
HPLC methods coupled online with ICP-MS and electrospray tandem mass spectrometry and high-resolution mass spectrometry are developed and applied for elemental speciation analysis in marine samples, foods, and biological materials. The objective is to provide data on the metal species present and their quantities. This is needed for accurate risk assessments to be possible.

Metalloproteomics and Metallomics
We aim to develop sensitive and selective analytical methods, suitable for detecting metals interacting with proteins or metalloproteins in biological materials. Comparative metalloproteomics are conducted to investigate the effect of external factors on metalloprotein content. A variety of novel analytical methods are being developed for this purpose.

Metal Determination in Single Cells
Similar to single particle ICP-MS, single cell ICP-MS is also being investigated as an approach to determine metal content in individual cells. In this case, microfluidics chips are also being used for cell sorting and ICP-MS analysis.

Mass Spectrometric Research
We are also interested in exploring new ionization methods in mass spectrometry, i.e. sonic spray in particular, in an attempt to understand its ionization mechanism and to find ways to improve its efficiency, as well as find unique applications for this mode of ionization (analysis of coordination compounds, peptides and proteins, native state MS). Emphasis is placed on identifying differences and advantages over electrospray ionization. A prototype source is being developed.