Welcome to Laboratory of Biophysical Chemistry

Selected Publications

• Zhang, L.; Isselstein, M.; Köhler, J.; Eleftheriadis, N.; Huisjes, N.M.; Guirao-Ortiz, M.; Narducci, A.; Smit, J.H.; Stoffels, J.; Harz, H.; Leonhardt, H.; Herrmann, A.; Cordes, T. Linker Molecules Convert Commercial Fluorophores into Tailored Functional Probes during Bio-labeling. Angew. Chemie Int. Ed. 2022, e202112959
• Krishnamurthy, S.; Sardis, M.F.; Eleftheriadis, N.; Chatzi, K.E.; Smit, J; Karathanou, K.; Gouridis, G.; Portaliou, A; Bondar, A.N; Karamanou, S; Economou A. Preproteins couple the intrinsic dynamics of SecA to its ATPase cycle to translocate via a catch and release mechanism. Cell Reports 2022, 38 (6), 110346
• Eleftheriadis, N.; Krishnamurthy, S.; Karathanou, K.; Smit, J; Portaliou, A; Chatzi, K.E.; Karamanou, S; Bondar, A.N; Gouridis, G.; Economou A. A nexus of intrinsic dynamics underlies translocase priming Structure 2021, 29, 1-13
• de Boer, M.; Gouridis, G.; Vietrov, R.; Begg, S. L.; Schuurman-Wolters. G.K.; Husada, F.; Eleftheriadis, N.; Poolman, B.; McDevitt, C. A.; Cordes, T. Conformational and dynamic plasticity in substrate-binding proteins underlies selective transport in ABC importers. E-life, 2019, 8, e44652
• Eleftheriadis, N.; Wojcik, M.; Zwinderman, M. R. H.; Dömling, A.; Dekker, F. J.; Boersma Y. Identification of potential antivirulence agents by substitution-oriented screening for inhibitors of Streptococcus pyogenes Sortase A. Eur. J. Med. Chem. 2019, 161, 93–100
• Eleftheriadis, N.; Thee, S. A.; Zwinderman, M. R. H.; Leus, N. G. J.; Dekker, F. J. Activity‐Based Probes for 15‐Lipoxygenase‐1. Angew. Chemie Int. Ed. 2016, 55, 12300 –12305
• Eleftheriadis, N.; Poelman, H.; Leus, N. G. J.; Honrath, B.; Neochoritis, C. G.; Dolga, A.; Dömling, A.; Dekker, F. J. Design of a Novel Thiophene Inhibitor of 15-Lipoxygenase-1 with Both Anti-Inflammatory and Neuroprotective Properties. Eur. J. Med. Chem. 2016, 122, 786–801