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Professor Ioulia Smonou web: http://www.chemistry.uoc.gr/organic |
Research InterestsBrief Biography
B.Sc. in Chemistry (1980), University of Athens, Dept. of Chemistry, Greece; Ph.D. in Organic Chemistry (1985), National Research Institute and University of Athens, Greece; Postdoctoral Research Fellow 1985-1986, University of California Los Angeles with Prof. M. E. Jung; Research Associate 1986-1989, Dept. of Chemistry, University of Crete, GR; Postdoctoral Research Fellow 1987 (summer), University of California Los Angeles with Prof. C. S. Foote; Instructor of Organic Chemistry 1989-1992, Dept. of Chemistry, University of Crete, GR; Lecturer of Organic Chemistry 1992-1998, Dept. of Chemistry, University of Crete, GR; Assistant Professor in Organic Chemistry 1998-2002, Dept. of Chemistry, University of Crete, GR; Tenured Assistant Professor in Organic Chemistry 2003-2005, Dept. of Chemistry, Univ. Of Crete, GR; Associate Professor 2005-present, Dept. of Chemistry, University of Crete, GR; Visiting Professor 2006, California Institute of Technology (Caltech), Division of Chemistry & Chem. Engineering, (Prof. Frances Arnold). Vice-chair, Dept. of Chemistry, University of Crete, 2008-2010.2010. Professor 2020-present Dept. of Chemistry, UoC.
Representative Publications
1. K. Velonia, I. Tsigos, V. Bouriotis* and I. Smonou* Bioorg.& Med. Chem. Lett. 1999, 9(1), 65-68.
“Stereospecificity of Hydrogen Transfer by the NAD+-linked Alcohol Dehydrogenase from the Antarctic Psychrophile Moraxella sp.TAE 123”.
doi:10.1016/S0960-894X(98)00678-7
2. I. Smonou* and K. Velonia Tetrahedron Asymmetry 2001,12:22, 3119-3123.
“Stereospecificity of Hydride Transfer During the Dismutation of Aldehydes Catalyzed by Alcohol Dehydrogenases”.
doi:10.1016/S0957-4166(01)00551-1
3. I. Smonou* and D. J. Bougioukou Tetrahedron Lett, 2002, 43, 339-342.
“Chloroperoxidase –Catalyzed Oxidation of Conjugated Dienoic Esters”.
doi:10.1016/S0040-4039(01)02127-X
4. I. Smonou*, D. Dafnomili and N. S. Hatzakis J. Mol. Cat. B: Enzymatic 2003, 21, 309-311.“Ferulic acid esterase from Humicola Insolens catalyzes enantioselective transesterification of secondary alcohols”.
doi:10.1016/S1381-1177(02)00228-X
5. N. Hatzakis and I. Smonou*, Tetrahedron Letters, 2004, 45/13 , 2755-2757.
“Enantioselectivity and diastereoselectivity in the transesterification of secondary alcohols mediated by feruloyl esterase from Humicola insolens”.
doi:10.1016/j.tetlet.2004.02.034
6. N. Hatzakis and I. Smonou*, Bioorganic Chemistry 2005, 33, 325-337.
“Asymmetric transesterification of secondary alcohols catalyzed by feruloyl esterase from Humicola Insolens”.
doi:10.1016/j.bioorg.2005.05.002
7. D. Kalaitzakis, D. J. Rozzell, S. Kambourakis and I. Smonou*, Org. Lett. 2005, 7, 4799-4801.
“Highly Stereoselective Reductions of a-alkyl-1,3-diketones and a-alkyl-b-keto esters catalyzed by isolated NADPH-dependent Ketoreductases”.
pubs.acs.org/doi/full/10.1021/ol051166d
8. D. Kalaitzakis, D. J. Rozzell, S. Kambourakis and I. Smonou*, Eur. J. Org. Chem. 2006, 2309-2313.
“A two-step chemoenzymatic synthesis of the natural pheromone (+)-Sitophilure utilizing an isolated, NADPH-dependent ketoreductase”.
doi:10.1002/ejoc.200500991
9. D. Kalaitzakis, D. J. Rozzell, S. Kambourakis and I. Smonou*, Adv. Synth. Cat 2006, 348,1958-1969.
“Synthesis of Valuable Chiral Intermediates by Isolated Ketoreductases: Application in the Synthesis of a-Alkyl-b-hydroxy Ketones and 1,3-Diols”.
doi:10.1002/adsc.200606185
10. D. Kalaitzakis, D. J. Rozzell, S. Kambourakis and I. Smonou*, Tetrahedron Asymmetry, 2007, 18, 2418-2426.
“Stereoselective Chemoenzymatic Synthesis of Sitophilate: A Natural Pheromone”.
doi:10.1016/j.tetasy.2007.10.008
11. Kalaitzakis, D.; Smonou, I. J. Org. Chem. 2008, 73, 3919-3921.
“A Convenient Method for the Assignment of Relative Configuration of Acyclic a-Alkyl-b-hydroxy Carbonyl Compounds by 1H NMR”.
http://pubs.acs.org/doi/full/10.1021/jo800066a
12. Dimitris Kalaitzakis, Ioulia Smonou Tetrahedron 2010, , 66, 9431-9439.
“Highly diastereoselective synthesis of 2-substituted-1,3-diols catalyzed by Ketoreductases”.
doi:10.1016/j.tet.2010.09.096
13. Kalaitzakis, D.; Smonou, I. J. Org. Chem. 2010, 75, 8658-8661.
“A two-step, one-pot enzymatic synthesis of 2-substituted-1,3-diols”
http://pubs.acs.org/doi/pdf/10.1021/jo101519t
14. Kallergi, M.; Kalaitzakis, D.; Smonou, I. Eur. J. Org. Chem. 2011, 3946-3950. Special Issue Women in Chemistry.
”FEnzymatic Total Synthesis of Banana Volatile (S)-2-Pentyl (R)-3-Hydroxyhexanoate”
http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201100368/abstract
15. Kalaitzakis, D.; Smonou, I Eur. J. Org. Chem. 2012, 43-46.
”Chemoenzymatic Synthesis of Stegobinone and Stegobiol, the Natural Sex Pheromone of the Drugstore Beetle (Stegobium paniceum L.)” Cover picture
http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201190107/abstract
16. Bariotaki A., Kalaitzakis D., Smonou I. Org. Lett. 2012, 14(7), 1792-1795
”Enzymatic Reductions for the Regio- and Stereoselective Synthesis of hydroxy-keto esters and dihydroxy esters”
http://pubs.acs.org/doi/ipdf/10.1021/ol3003833
17. Anastasios Stergiou, Anna Bariotaki, Dimitris Kalaitzakis, Ioulia Smonou J. Org. Chem. 2013, Article ASAP
”Oxone Mediated Oxidative Cleavage of ?-Ketoesters and 1,3-Diketones to ??Ketoesters and 1,2-Diketones in Aqueous Medium”
http://pubs.acs.org/doi/ipdf/10.1021/jo4009047