Our Approach

we have a strong focus on synthetic organic chemistry and
the basic tool of our strategy are Multi-Component Reactions (MCRs)

Our Chemistry provides:

Diversity and Convergence
Complexity generation
Time/resourse saving
Easiness of performance
  1. Expanding the chemical space - we discover new Multi-Component reactions employing different building blocks based on their different functionalities. Our target; Novel scaffolds, libraries ready to be screened
  2. Molecule Functionalization via MCRs (1) - we offer alternative and more efficient synthetic pathways towards molecules of interest; pharmaceuticals and agrochemicals
  3. Molecule Functionalization via MCRs (2) - we target unprecedented organic materials

Our Awesome Team

Dr Constantinos Neochoritis

Assistant Professor

Xiaofang Lei

PhD student

Michalis Fragiadakis

PhD student

Maria Thomaidi

MSc student

Zoi Kardasi 

BSc student

Maria Gaidatzi

BSc student

Marios Zingiridis

BSc student

past members

BSc thesis (2019-2020)

BSc thesis (2019-2020)

BSc thesis (2020-2021)

BSc thesis (2020-2021)


Recent Publications

X. Lei, P. Lampiri, P. Patil, G. Angeli, C. G. Neochoritis,* A. Dömling*, ChemComm 2021, 57, 6652-6655.
2. X. Lei, M. Thomaidi, G. K. Angeli, A. Dömling*, C. G. Neochoritis*, Synlett 2021, in press (10.1055/a-1471-9080).
3. N. Griboura, K. Gatzonas, C. G. Neochoritis*, Chemmedchem 2021, 16, 1997-2020.
4. N. Tripolitsiotis, M. Thomaidi, C. G. Neochoritis*, Eur. J. Org. Chem. 2020, 6525-6554.
5. F. Sutanto, S. Shaabani, C. G. Neochoritis, T. Zarganes-Tzitzikas, P. Patil, E. Ghonchepour, A. Dömling, Science Advances 2021, 7, eabd9307 
6. C. G. Neochoritis, T. Zarganes-Tzitzikas, K. Katsampoxaki-Hodgetts, A. Dömling, J. Chem. Educ. 2020, 97, 3739-3745.
7. M. G. Ricardo, A. M. Ali, J. Plewka, E. Surmiak, B. Labuzek, C. G. Neochoritis, J. Atmaj, L. Skalniak, R. Zhang, T. A. Holak, M. Groves, D. G. Rivera, A. Dömling, Angew. Chem. Int. Ed. 2020, 59, 5235-5241.
8. C. G. Neochoritis, T. Zarganes-Tzitzikas, M. Novotná, T. Mitríková, Z. Wang, K. Kurpiewska, J. Kalinowska-Tłuścik, Alexander Dömling, Eur. J. Org. Chem. 2019, 35, 6132-6137.
9. C. G. Neochoritis, S. Shaabani, M. Ahmadianmoghaddam, T. Zarganes-Tzitzikas, L. Gao, M. Novotná, T. Mitríková, A. Reyes Romero, M. I. Irianti, R. Xu, J. Olechno, R. Ellson, V. Helan, M. Kossenjans, M. R. Groves, A. Dömling, Science Advances 2019, 5, eaaw4607.
10. C. G. Neochoritis, J. Atmaj, A. Twarda-Clapa, E. Surmiak, L. Skalniak, L.M. Köhler, D. Muszak, K. Kurpiewska, J. Kalinowska-Tłuścik, B. Beck, T. A. Holak, A. Dömling, Eur. J. Med. Chem. 2019, 111588.



Chemistry department, University of Crete, Heraklion, Greece





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