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Our Approach

we have a strong focus on synthetic organic chemistry and
the basic tool of our strategy are Multi-Component Reactions (MCRs)

Our Chemistry provides:

Diversity and Convergence
Complexity generation
Time/resourse saving
Easiness of performance
  1. Expanding the chemical space - we discover new Multi-Component reactions employing different building blocks based on their different functionalities. Our target; Novel scaffolds, libraries ready to be screened
  2. Molecule Functionalization via MCRs (1) - we offer alternative and more efficient synthetic pathways towards molecules of interest; pharmaceuticals and agrochemicals
  3. Molecule Functionalization via MCRs (2) - we target unprecedented organic materials

Our Awesome Team

Dr Constantinos Neochoritis

Assistant Professor

Xiaofang Lei

PhD student

Maria Thomaidi

MsC student

Nefeli Griboura

BsC student

Nikolaos Tripolitsiotis

BsC student

Past Members

Recent Publications

 M. G. Ricardo, A. M. Ali, J. Plewka, E. Surmiak, B. Labuzek, C. G. Neochoritis, J. Atmaj, L. Skalniak, R. Zhang, T. A. Holak, M. Groves, D. G. Rivera, A. Dömling, Angew. Chem. Int. Ed. 2020, 59, 5235-5241.
2. C. G. Neochoritis, T. Zarganes-Tzitzikas, M. Novotná, T. Mitríková, Z. Wang, K. Kurpiewska, J. Kalinowska-Tłuścik, Alexander Dömling, Eur. J. Org. Chem. 2019, 35, 6132-6137.
3. C. G. Neochoritis, S. Shaabani, M. Ahmadianmoghaddam, T. Zarganes-Tzitzikas, L. Gao, M. Novotná, T. Mitríková, A. Reyes Romero, M. I. Irianti, R. Xu, J. Olechno, R. Ellson, V. Helan, M. Kossenjans, M. R. Groves, A. Dömling, Science Advances 2019, 5, eaaw4607.
4. C. G. Neochoritis, J. Atmaj, A. Twarda-Clapa, E. Surmiak, L. Skalniak, L.M. Köhler, D. Muszak, K. Kurpiewska, J. Kalinowska-Tłuścik, B. Beck, T. A. Holak, A. Dömling, Eur. J. Med. Chem. 2019, 111588.
5. T. Zarganes-Tzitzikas, C. G. Neochoritis, A. Dömling, ACS Med. Chem. Lett. 2019, 10, 389 (most read of month March).
6. C. G. Neochoritis, T. Zhao, A. Dömling, Chem.Rev. 2019, 119, 1970-2042 (most read of month February).
7. L. Skalniak, A. Twarda-Clapa, C. G. Neochoritis, E. Surmiak, M. Machula, A. Wisniewska, B. Labuzek, A. M. Ali, S. Krzanik, G. Dubin, M. Groves, A. Dömling, T. A. Holak FEBS 2019, 1360-1374.



Chemistry department, University of Crete, Heraklion, Greece




We are always looking for enthousiastic researchers from around the world!

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