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Our Approach

we have a strong focus on synthetic organic chemistry and
the basic tool of our strategy are Multi-Component Reactions (MCRs)

Our Chemistry provides:

More about MCR chemistry
Diversity and Convergence
Complexity generation
Time/resourse saving
Easiness of performance
  1. Expanding the chemical space - we discover new multicomponent reactions employing different building blocks based on their different functionalities. Our target; Novel scaffolds, libraries ready to be screened against any target
  2. Drug Discovery - we offer alternative and more efficient synthetic pathways towards molecules of interest; generics, agrochemicals, design (cheminformatics, docking) and extensive SARs
  3. New Modalities - we target unprecedented scaffolds, macrocycles, glues, 3D molecules

Our Awesome Team

Dr Constantinos Neochoritis

Associate Professor

Maritina Giannakaki

PhD student

Danae Papachristodoulou

MSc student

Faye Kakari

MSc student

Katerina Christofaki

BSc student

Stavros Alatsakis

BSc student

Dimitris Mytakis

BSc student

past members

1. Konstantinos Gatzonas
2. Nefeli Griboura
3. Nikolaos Tripolitsiotis
4. Panagiota Lampiri
5. Maria Gaidatzi
6. Zoi Kardasi
7. Eleftheria Chatziorfanou
8. Michail Georgoulakis
9. Christina Tomza
10. Alexandros Vasilakis
11. Ioannis Volyrakis
12. Despoina Menegaki
13. Ioanna Petritaki
14. Danae Papachristodoulou
15. Stylianos Polychroniadis
16. Stavroula Xyrafaki
17. Despoina Kantartzoglou
18. Iakovos Konstantaras
19. Foteini Kakari
20. Alexandra Paraschaki
21. Nikol Giannoulaki

1. Aliki Fotiadi
2. Maria Thomaidi
3. Konstantinos Adamis
4. Marios Zingiridis
5. Paria Anastasiou
6. Konstantina Nikovia
7. Michalis Kapsalis

1. Xiaofang Lei
2. Michalis Fragiadakis

1. Eirini Fotopoulou
2. Michalis Fragiadakis

Mobirise

Recent selected publications


1. M.A. Giannakaki, M. Zingiridis, K. G. Froudas, C. G. Neochoritis*, OrgLett 2026, 28, 2096.
2. M. Georgoulakis, I. Angelonidis, K. G. Froudas, N. Eleftheriadis, C. G. Neochoritis*, OBC 2025, 23, 10679.
3. Markella Konstantinidou, Marios Zingiridis, Marloes A.M. Pennings, Michael Fragkiadakis, Johanna M. Virta, Jezrael L. Revalde, Emira J. Visser, Christian Ottmann, Luc Brunsveld, Constantinos G. Neochoritis, Michelle R. Arkin, NatComm 2025, 16, 6467. 
4. K. S. Adamis, M. Georgoulakis, I. Angelonidis, D. Korovesis, C. Papadopoulos, M. Kapsalis, N. Tavernarakis, N. Eleftheriadis,* C. G. Neochoritis*, ChemAEurJ 2025, e202501513.
5. M. Fragkiadakis, T. Stergiannakos, N. D. Charistos, A. G. Papadopoulos, C. C. Stoumpos, C. G. Neochoritis, EurJOC 2025, e202500212.
6. P.K Anastasiou, M. Fragkiadakis, M. Thomaidi, K.G. Froudas, C. G. Neochoritis, OrgLett 2025, 27, 1829-1834.
7. M. Zingiridis, D. Papachristodoulou, D. Menegaki, K.G. Froudas, C.G. Neochoritis, BJOC 2025, 21, 217-225.
8. M. Fragkiadakis, M. Thomaidi, T. Stergiannakos, E. Chatziorfanou, M. Gaidatzi, A. Barakat, C. Stoumpos, C.G. Neochoritis ChemAEurJ 2024, 30, e202401461.
9. M. Fragkiadakis, P.K Anastasiou, I. Volyrakis, A. Pantousas, C.C. Stoumpos, C.G. Neochoritis, ChemComm 2023, 59, 14411-14414.
10. M. Fragkiadakis, P.K. Anastasiou, M. Zingiridis, M.E. Triantafyllou-Rundell, A. Reyes Romero, C. C. Stoumpos, C. G. Neochoritis, J. Org. Chem. 2023, 88, 12709-12715.

Our Latest News

The latest news, results and ongoing stuff of our group

Mobirise

Publication

The power of MCRs: 6 different simple building blocks to fully functionalized fused hydantoins and diketopiperazines. Check it out:
10.1021/acs.orglett.5c05391

Mobirise

Chemistry Europe

Prof Neochoritis  was named a Fellow of Chemistry Europe (class of 2024/2025) for his exceptional support and contributions to the Chemistry Europe.

Mobirise

Publication

Scaffold hoping targeting the 14-3-3/ERα complex, opening new horizons in the fight against breast cancer. Check it out:
10.1038/s41467-025-61176-4

funding...

HFRI

Hellenic Foundation of
Research & Innovation ELKE@UoC TelesisPharma Empirikion Idryma

find out more...

Principle
Investigator MACRO Scopus Our lab
Mobirise

Contact

Address:

Chemistry department, University of Crete, Heraklion, Greece

Phone:

+302810545024

E-mail:

kneochor@uoc.gr


We are always looking for enthousiastic researchers from around the world!

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